Short-term intermittent cigarette smoke exposure enhances alveolar type 2 cell stemness via fatty acid oxidation.

Hidehiro IrieMari OzakiShotaro ChubachiAhmed E HegabAkihiro TsutsumiNaofumi KameyamaKaori SakuraiShingo NakayamaShizuko KagawaSachika WadaMakoto IshiiTomoko BetsuyakuKoichi Fukunaga

Published in: Respiratory research (2022)

Alveolar stem cell function was more strongly activated by intermittent CS exposure than by continuous CS exposure. We provide evidence that AT2 stem cells respond to intermittent CS exposure by activating stem cell proliferation via the activation of FAO.

Keyphrases

stem cells
cell therapy
fatty acid
high intensity
epithelial mesenchymal transition
single cell
nitric oxide
bone marrow