A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study.
Simona TerzoAntonella AmatoAntonio Magan-FernándezGiuseppa CastellinoPasquale CalviRoberta ChianettaRosaria V GiglioAngelo M PattiDragana NikolicAlberto FirenzeFlavia MulèMarcello CiaccioManfredi RizzoPublished in: Nutrients (2023)
Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes. Our previous study demonstrated that a Cynara cardunculus (L.) based nutraceutical named Altilix® (Bionap, Italy), containing chlorogenic acid and luteolin extracts, was able to improve several hepatic and cardio-metabolic parameters. Given this background, we conducted a post-hoc analysis of the Altilix® study in order to analyze the supplement’s effects in the subgroup of pre-obesity subjects on anthropometry (weight and waist circumference), glucose metabolism (HbA1C, HOMA-IR, and HOMA-β), lipid profile (total cholesterol, triglycerides, LDL-cholesterol and HDL-cholesterol), hepatic functionality (FLI, AST, ALT and AST/ALT), carotid-media thickness (CIMT) and endothelial function (FMD). Fifty subjects from the original study cohort (which consisted of 100 subjects) were chosen with BMI ≥ 25 and < 30 kg/m2. All subjects received the Altilix® supplement (150 mg/day) or placebo using a computer-based random allocation system. After six months of treatment Altilix® significantly reduced body weight, glycemic, and lipid parameters (total cholesterol, triglycerides, LDL-cholesterol) and improved hepatic functionality, CIMT, and FMD. In conclusion, these results confirm that Altilix® supplementation has a significant effect on cardiometabolic parameters not only in obese subjects but also in pre-obesity subjects.
Keyphrases
- weight loss
- type diabetes
- metabolic syndrome
- double blind
- body weight
- insulin resistance
- weight gain
- low density lipoprotein
- body mass index
- high fat diet induced
- cardiovascular disease
- bariatric surgery
- glycemic control
- phase iii
- randomized controlled trial
- deep learning
- open label
- machine learning
- skeletal muscle
- physical activity
- study protocol
- cardiovascular events