Concurrent Administration of Immune Checkpoint Inhibitors and Stereotactic Radiosurgery Is Well-Tolerated in Patients With Melanoma Brain Metastases: An International Multicenter Study of 203 Patients.
Eric J LehrerJason GurewitzKenneth BernsteinDouglas KondziolkaKareem R FakhouryChad G RusthovenAjay NiranjanZhishuo WeiL Dade LunsfordTimothy D MalouffHenry Ruiz-GarciaJennifer L PetersonPhillip BonneyLindsay HwangCheng YuGabriel ZadaChristopher P DeibertRahul N PrasadRaju R RavalJoshua D PalmerSamir PatelPiero PicozziAndrea FranziniLuca AttuatiDavid MathieuClaire TrudelCheng-Chia LeeHuai-Che YangBrianna M JonesSheryl GreenManmeet S AhluwaliaJason P SheehanDaniel M TrifilettiPublished in: Neurosurgery (2022)
Concurrent administration of ICIs and SRS are not associated with an increased risk of RN. Tumors harboring BRAF mutation, or perhaps prior exposure to targeted agents, may increase this risk. Radiosurgical optimization to maintain V12 < 10 cm 3 is a potential strategy to reduce the risk of RN.