Effectiveness and safety of tenofovir alafenamide in children and adolescents living with HIV: a systematic review.

John O'RourkeClaire L TownsendEdith MilanziIntira Jeannie CollinsHannah CastroAli JuddMarissa VicariJulie Jesson Valeriane Leroy Martina Penazzato Francoise Renaud

Published in: Journal of the International AIDS Society (2023)

Four single-arm trials were identified in this systematic review, with initial evidence suggesting good viral suppression and no obvious safety concerns in children and adolescents on TAF-containing regimens over 24-48 weeks. However, further comparative and longer-term safety data are needed in children and adolescents, including on weight and metabolic changes.

Keyphrases

systematic review
gestational age
meta analyses
sars cov
body mass index
physical activity
weight loss
preterm infants
electronic health record
big data
randomized controlled trial
body weight