YAP promotes autophagy and progression of gliomas via upregulating HMGB1.

Min ZhaoYu ZhangYang JiangKai WangXiang WangDing ZhouYan WangRutong YuXiu-Ping Zhou

Published in: Journal of experimental & clinical cancer research : CR (2021)

YAP promoted glioma progression by enhancing HMGB1-mediated autophagy, indicating that YAP-HMGB1 axis was a feasible therapeutic target for GBM. Our study revealed a clinical opportunity involving the combination of chemo-radiotherapy with pharmacological autophagy inhibition for treating GBM patients with YAP high expression.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
poor prognosis
early stage
photodynamic therapy
high grade
radiation therapy
radiation induced
single cell
squamous cell carcinoma
binding protein
cancer therapy
long non coding rna