Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.

Li XiangWenxu PanHuan ChenWenjun DuShuping XieXinhua LiangFangying YangRongwei NiuCanxin HuangMinan LuoYuxin XuLanlan GengSitang GongWanfu Xu Junhong Zhao

Published in: Mediators of inflammation (2024)

These findings suggested that sorbitol suppressed intestinal enteroids and M-cell differentiation and matured through PDE4-mediated RANKL expression; targeting to inhibit PDE4 was sufficient to induce M-cell development.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
nuclear factor
stem cells
cell death
signaling pathway
immune response
bone loss
inflammatory response
drug delivery
pi k akt
toll like receptor