Metatranscriptomic analysis to define the Secrebiome, and 16S rRNA profiling of the gut microbiome in obesity and metabolic syndrome of Mexican children.
Luigui Gallardo-BecerraFernanda Cornejo-GranadosRodrigo García-LópezAlejandra Valdez-LaraShirley BikelSamuel Canizales-QuinterosBlanca E López-ContrerasAlfredo Mendoza-VargasHenrik NielsenOchoa-Leyva AdrianPublished in: Microbial cell factories (2020)
These findings show, for the first time, the role of the Secrebiome in the functional human-microbiota interaction. Our results highlight the importance of metatranscriptomics to provide novel information about the gut microbiome's functions that could help us understand the impact of the Secrebiome on the homeostasis of its human host. Furthermore, the metatranscriptome and 16S profiling confirmed the importance of treating obesity and obesity with metabolic syndrome as separate conditions to better understand the interplay between microbiome and disease.
Keyphrases
- metabolic syndrome
- insulin resistance
- endothelial cells
- weight loss
- uric acid
- high fat diet induced
- type diabetes
- weight gain
- induced pluripotent stem cells
- cardiovascular risk factors
- pluripotent stem cells
- single cell
- young adults
- healthcare
- skeletal muscle
- cardiovascular disease
- health information
- social media
- physical activity