Diagnostic performance of 18 F-FDG-PET/CT compared to standard skeletal survey for detecting bone destruction in smouldering multiple myeloma: time to move forward.
Elizabeth HillEsther MenaCandis MorrisonAlexander DewPeter ChoykeLiza LindenbergDickran KazandjianPublished in: British journal of haematology (2020)
Skeletal survey (SS) continues to be used in the community to detect bone disease in patients with multiple myeloma (MM). While the false-negative rate is high, the specificity of SS is less well characterised. Here, we compare the diagnostic accuracy of SS compared to 18 F-FDG-PET/CT (positron emission tomography/computed tomography) in 79 patients referred to our tertiary centre with a diagnosis of smouldering MM. SS had a specificity of 83·1% (95% confidence interval: 72·0-90·5%). This study reinforces the importance of using more specific imaging techniques to avoid inaccurate diagnosis that could lead to the risks associated with unnecessary therapy in patients with smouldering MM.
Keyphrases
- positron emission tomography
- computed tomography
- multiple myeloma
- end stage renal disease
- ejection fraction
- bone mineral density
- newly diagnosed
- magnetic resonance imaging
- chronic kidney disease
- high resolution
- cross sectional
- healthcare
- pet ct
- peritoneal dialysis
- mental health
- soft tissue
- prognostic factors
- stem cells
- mass spectrometry
- bone loss
- patient reported outcomes
- human health
- risk assessment
- photodynamic therapy
- mesenchymal stem cells
- structural basis
- cell therapy
- body composition
- replacement therapy