A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension.

Xincheng LiShuangshuang MaQi WangYishan LiXiaofan JiJixiang LiuJing MaYongbing WangZhu ZhangHong ZhangHong ChenLinfeng XiYunxia ZhangWanmu XieLu SunZhihui FuPeiran YangChen WangZhen-Guo Zhai

Published in: Journal of translational medicine (2024)

Our study identified a new inflammatory pathway in IPAH, where T and NK cells drove heightened inflammation predominantly via the upregulation of CCL5, providing groundwork for the development of targeted therapeutics.

Keyphrases

nk cells
rna seq
single cell
pulmonary arterial hypertension
oxidative stress
pulmonary artery
induced apoptosis
pulmonary hypertension
high throughput
liver fibrosis
liver injury
cell cycle arrest
cell proliferation
poor prognosis
signaling pathway
coronary artery
cancer therapy
african american
long non coding rna