Antinociceptive effects of novel histamine H3 and H4 receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse.

Katarzyna Popiolek-BarczykDorota ŁażewskaGniewomir LataczAgnieszka OlejarzWioletta MakuchHolger StarkKatarzyna Kieć-KononowiczJoanna Mika

Published in: British journal of pharmacology (2018)

We describe a therapeutic use for new H3 (E-162) and H4 receptor (TR-7) antagonists in neuropathy. Targeting H3 and H4 receptors enhanced morphine analgesia, consistent with multimodal pain therapy.

Keyphrases

neuropathic pain
pain management
spinal cord
spinal cord injury
chronic pain
ultrasound guided
postoperative pain
anti inflammatory
stem cells
binding protein
replacement therapy
smoking cessation