Holger Stark

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 74

Top Topics

Molecular Dynamics Simulations

Neuropathic Pain

Atopic Dermatitis

Top Venues

Molecules (Basel, Switzerland)

International journal of molecular sciences

ACS chemical neuroscience

British journal of pharmacology

This page only lists publications with an associated author ORCID identifier.

Publications

Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H 3 Receptors and Cholinesterases. ACS chemical neuroscience (2024)
Cristian Di Biase, Luisa Leitzbach, Annika Frank, Aleksandra Zivkovic, Holger Stark
Aromatic linker variations in novel dopamine D 2 and D 3 receptor ligands. Archiv der Pharmazie 357 (8) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H 3 Receptors and Cholinesterases. ACS chemical neuroscience 15 (6) (2024)
Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H 3 Receptors and Cholinesterases. ACS chemical neuroscience 15 (6) (2024)
Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H 3 Receptors and Cholinesterases. ACS chemical neuroscience 15 (6) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H 3 Receptors and Cholinesterases. ACS chemical neuroscience 15 (6) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Paula Morales, Magdalena M Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K Hansen, Nadine Jagerovic, Jan Jakubík, György M Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo-Abreu, Gemma Navarro, Rubén Prieto-Díaz, Mette Marie Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M Wingler
Progress on the development of Class A GPCR-biased ligands. British journal of pharmacology (2024)
Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H 3 Receptors and Cholinesterases. ACS chemical neuroscience 15 (6) (2024)
Janine Kutzsche, Gustavo A Guzman, Antje Willuweit, Olaf Kletke, Esther Wollert, Ian Gering, Dagmar Jürgens, Jörg Breitkreutz, Holger Stark, Annette G Beck-Sickinger, Nikolaj Klöcker, Patricia Hidalgo, Dieter Willbold
An orally available Ca v 2.2 calcium channel inhibitor for the treatment of neuropathic pain. British journal of pharmacology 181 (12) (2024)
Cristian Di Biase, Luisa Leitzbach, Annika Frank, Aleksandra Zivkovic, Holger Stark
Aromatic linker variations in novel dopamine D 2 and D 3 receptor ligands. Archiv der Pharmazie (2024)
Janine Kutzsche, Gustavo A Guzman, Antje Willuweit, Olaf Kletke, Esther Wollert, Ian Gering, Dagmar Jürgens, Jörg Breitkreutz, Holger Stark, Annette G Beck-Sickinger, Nikolaj Klöcker, Patricia Hidalgo, Dieter Willbold
An orally available Ca v 2.2 calcium channel inhibitor for the treatment of neuropathic pain. British journal of pharmacology 181 (12) (2024)
Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński
Guanidines: Synthesis of Novel Histamine H 3 R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect. Pharmaceuticals (Basel, Switzerland) 16 (5) (2023)
Agnieszka Olejarz-Maciej, Szczepan Mogilski, Tadeusz P Karcz, Tobias Werner, Katarzyna Kamińska, Jarosław Kupczyk, Ewelina Honkisz-Orzechowska, Gniewomir Latacz, Holger Stark, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Trisubstituted 1,3,5-Triazines as Histamine H 4 Receptor Antagonists with Promising Activity In Vivo. Molecules (Basel, Switzerland) 28 (10) (2023)
Katarzyna Szczepańska, Tadeusz Karcz, Maria Dichiara, Szczepan Mogilski, Justyna Kalinowska-Tłuścik, Bogusław Pilarski, Arkadiusz Leniak, Wojciech Pietruś, Sabina Podlewska, Katarzyna Popiołek-Barczyk, Laura J Humphrys, Ma Carmen Ruiz Cantero, David Reiner-Link, Luisa Leitzbach, Dorota Łażewska, Steffen Pockes, Michał Górka, Adam Zmysłowski, Thierry Calmels, Enrique J Cobos, Agostino Marrazzo, Holger Stark, Andrzej J Bojarski, Emanuele Amata, Katarzyna Kieć-Kononowicz
Dual Piperidine-Based Histamine H 3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. Journal of medicinal chemistry (2023)
Dorota Łażewska, Maria Kaleta, Paula Zaręba, Justyna Godyń, Mariam Dubiel, Ewelina Honkisz-Orzechowska, Agata Doroz-Płonka, Anna Więckowska, Holger Stark, Katarzyna Kieć-Kononowicz
Multitargeting Histamine H 3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives. Molecules (Basel, Switzerland) 28 (5) (2023)
Dorota Łażewska, Maria Kaleta, Paula Zaręba, Justyna Godyń, Mariam Dubiel, Ewelina Honkisz-Orzechowska, Agata Doroz-Płonka, Anna Więckowska, Holger Stark, Katarzyna Kieć-Kononowicz
Multitargeting Histamine H 3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives. Molecules (Basel, Switzerland) 28 (5) (2023)
Janine Kutzsche, Gustavo A Guzman, Antje Willuweit, Olaf Kletke, Esther Wollert, Ian Gering, Dagmar Jürgens, Jörg Breitkreutz, Holger Stark, Annette G Beck-Sickinge, Nikolaj Klöcker, Patricia Hidalgo, Dieter Willbold
An orally available N-type calcium channel inhibitor for the treatment of neuropathic pain. British journal of pharmacology (2023)
Dorota Łażewska, Maria Kaleta, Paula Zaręba, Justyna Godyń, Mariam Dubiel, Ewelina Honkisz-Orzechowska, Agata Doroz-Płonka, Anna Więckowska, Holger Stark, Katarzyna Kieć-Kononowicz
Multitargeting Histamine H 3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives. Molecules (Basel, Switzerland) 28 (5) (2023)
Janine Kutzsche, Gustavo A Guzman, Antje Willuweit, Olaf Kletke, Esther Wollert, Ian Gering, Dagmar Jürgens, Jörg Breitkreutz, Holger Stark, Annette G Beck-Sickinger, Nikolaj Klöcker, Patricia Hidalgo, Dieter Willbold
An orally available Ca v 2.2 calcium channel inhibitor for the treatment of neuropathic pain. British journal of pharmacology (2023)
Nermin Eissa, Mohamed Al Awad, Shilu Deepa Thomas, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Sicheng Zhong, Holger Stark, Bassem Sadek
Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice. International journal of molecular sciences 24 (1) (2022)
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Benzophenone Derivatives with Histamine H 3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease. Molecules (Basel, Switzerland) 28 (1) (2022)
Karthikkumar Venkatachalam, Sicheng Zhong, Mariam Dubiel, Grzegorz Satała, Bassem Sadek, Holger Stark
The Novel Pimavanserin Derivative ST-2300 with Histamine H 3 Receptor Affinity Shows Reduced 5-HT 2A Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice. Biomolecules 12 (5) (2022)
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Benzophenone Derivatives with Histamine H 3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease. Molecules (Basel, Switzerland) 28 (1) (2022)
Nermin Eissa, Mohamed Al Awad, Shilu Deepa Thomas, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Sicheng Zhong, Holger Stark, Bassem Sadek
Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice. International journal of molecular sciences 24 (1) (2022)
Christian Espinosa-Bustos, Luisa Leitzbach, Tito Añazco, María J Silva, Andrea Del Campo, Alejandro Castro-Alvarez, Holger Stark, Cristian O Salas
Substituted Purines as High-Affinity Histamine H 3 Receptor Ligands. Pharmaceuticals (Basel, Switzerland) 15 (5) (2022)
Nermin Eissa, Mohamed Al Awad, Shilu Deepa Thomas, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Sicheng Zhong, Holger Stark, Bassem Sadek
Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice. International journal of molecular sciences 24 (1) (2022)
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Gabriel Santos, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C Brüning, Bengt-Frederik Belgardt
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature cell biology 25 (1) (2022)
M Hanief Sofi, Linlu Tian, Steven Schutt, Imran Khan, Hee-Jin Choi, Yongxia Wu, David Bastian, Taylor Ticer, Mohamed Faisal Kassir, Firdevs Cansu Atilgan, Jisun Kim, Xiaohui Sui, Aleksandra Zivkovic, Shikhar Mehrotra, John P O'Bryan, Holger Stark, Paul J Martin, Besim Ogretmen, Xue-Zhong Yu
Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. Leukemia 36 (7) (2022)
Vaibhav Jain, Sandra L Harper, Amanda M Versace, Dylan F Fingerman, Gregory Schuyler Brown, Monika Bhardwaj, Mary Ann S Crissey, Aaron R Goldman, Gordon Ruthel, Jingjing Liu, Aleksandra Zivkovic, Holger Stark, Meenhard Herylyn, Phyllis A Gimotty, David W Speicher, Ravi K Amaravadi
Targeting UGCG overcomes resistance to lysosomal autophagy inhibition. Cancer discovery (2022)
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Gabriel Santos, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C Brüning, Bengt-Frederik Belgardt
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature cell biology (2022)
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Gabriel Santos, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C Brüning, Bengt-Frederik Belgardt
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature cell biology 25 (1) (2022)
Mihajlo Gajic, Damijan Knez, Gobec Izidor Sosič, Janez Mravljak, Anže Meden, Urban Košak, Luisa Leitzbach, Sven George, Bettina Hofmann, Aleksandra Zivkovic, Dieter Steinhilber, Holger Stark, Stanislav Gobec, Andrija Šmelcerović, Marko Anderluh
Repurposing of 8-Hydroxyquinoline-Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors. ChemMedChem 17 (5) (2022)
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Benzophenone Derivatives with Histamine H 3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease. Molecules (Basel, Switzerland) 28 (1) (2022)
Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak
Dual Targeting Ligands-Histamine H 3 Receptor Ligands with Monoamine Oxidase B Inhibitory Activity-In Vitro and In Vivo Evaluation. Pharmaceutics 14 (10) (2022)
Margherita Mastromarino, Mauro Niso, Carmen Abate, Ewgenij Proschak, Mariam Dubiel, Holger Stark, Marián Castro, Enza Lacivita, Marcello Leopoldo
Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties. Molecules (Basel, Switzerland) 27 (4) (2022)
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Gabriel Santos, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C Brüning, Bengt-Frederik Belgardt
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature cell biology 25 (1) (2022)
Nermin Eissa, Mohamed Al Awad, Shilu Deepa Thomas, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Sicheng Zhong, Holger Stark, Bassem Sadek
Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice. International journal of molecular sciences 24 (1) (2022)
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Gabriel Santos, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C Brüning, Bengt-Frederik Belgardt
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature cell biology 25 (1) (2022)
Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Priya Yuvaraju, Markus Falkenstein, Holger Stark, Bassem Sadek
Experimental Studies Indicate That ST-2223, the Antagonist of Histamine H3 and Dopamine D2/D3 Receptors, Restores Social Deficits and Neurotransmission Dysregulation in Mouse Model of Autism. Pharmaceuticals (Basel, Switzerland) 15 (8) (2022)
Leonie Beyer, Aylin Sara Kabatas, Susanne Mommert, Holger Stark, Thomas Werfel, Ralf Gutzmer, Katrin Schaper-Gerhardt
Histamine Activates Human Eosinophils via H 2 R and H 4 R Predominantly in Atopic Dermatitis Patients. International journal of molecular sciences 23 (18) (2022)
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Gabriel Santos, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C Brüning, Bengt-Frederik Belgardt
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature cell biology 25 (1) (2022)
Divya Sekar, Christina Dillmann, Evelyn Sirait-Fischer, Annika F Fink, Aleksandra Zivkovic, Natalie Baum, Elisabeth Strack, Stephan Klatt, Sven Zukunft, Stefan Wallner, Arnaud Descot, Catherine Olesch, Priscila da Silva, Andreas von Knethen, Tobias Schmid, Sabine Grösch, Soni Savai Pullamsetti, Nerea Ferreirós, Ingrid Fleming, Sourav Ghosh, Carla V Rothlin, Holger Stark, Hind Medyouf, Bernhard Brüne, Andreas Weigert
Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. Cancer research 82 (8) (2022)
Markus Hartmann, Jessica Huber, Jan S Kramer, Jan Heering, Larissa Pietsch, Holger Stark, Dalibor Odadzic, Iris Bischoff, Robert Fürst, Martin Schröder, Masato Akutsu, Apirat Chaikuad, Volker Dötsch, Stefan Knapp, Ricardo M Biondi, Vladimir V Rogov, Ewgenij Proschak
Demonstrating Ligandability of the LC3A and LC3B Adapter Interface. Journal of medicinal chemistry 64 (7) (2021)
Milica Elek, Nemanja Djokovic, Annika Frank, Slavica Oljacic, Aleksandra Zivkovic, Katarina Nikolic, Holger Stark
Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands. Archiv der Pharmazie 354 (6) (2021)
Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej, Maria Kaleta, Holger Stark, Barbara Malawska, Katarzyna Kieć-Kononowicz
Biphenylalkoxyamine Derivatives-Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity. Molecules (Basel, Switzerland) 26 (12) (2021)
Marek Staszewski, Dominik Nelic, Jakub Jończyk, Mariam Dubiel, Annika Frank, Holger Stark, Marek Bajda, Jan Jakubík, Krzysztof Walczyński
Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists. ACS chemical neuroscience 12 (13) (2021)
Stefanie Hagenow, Anna Affini, Elsa Y Pioli, Sonja Hinz, Yan Zhao, Gregory Porras, Vigneshwaran Namasivayam, Christa Elisabeth Müller, Jian-Sheng Lin, Erwan Bezard, Holger Stark
Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson's Disease. Journal of medicinal chemistry 64 (12) (2021)
Jenny Wilzopolski, Manfred Kietzmann, Santosh Kumar Mishra, Holger Stark, Wolfgang Bäumer, Kristine Rossbach
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch. Biomolecules 11 (8) (2021)
Caroline Fischer, Annett Wilken-Schmitz, Victor Hernandez-Olmos, Ewgenij Proschak, Holger Stark, Ingrid Fleming, Andreas Weigert, Manuela Thurn, Martine Catharina Josephine Hofmann, Ernst R Werner, Gerd Geisslinger, Ellen Niederberger, Katrin Watschinger, Irmgard Tegeder
AGMO Inhibitor Reduces 3T3-L1 Adipogenesis. Cells 10 (5) (2021)
Kamil J Kuder, Magdalena Kotańska, Katarzyna Szczepańska, Kamil Mika, David Reiner, Holger Stark, Katarzyna Kieć-Kononowicz
Discovery of Potential, Dual-Active Histamine H3 Receptor Ligands with Combined Antioxidant Properties. Molecules (Basel, Switzerland) 26 (8) (2021)
Katarzyna Szczepańska, Sabina Podlewska, Maria Dichiara, Davide Gentile, Vincenzo Patamia, Niklas Rosier, Denise Mönnich, Ma Carmen Ruiz Cantero, Tadeusz Karcz, Dorota Łażewska, Agata Siwek, Steffen Pockes, Enrique J Cobos, Agostino Marrazzo, Holger Stark, Antonio Rescifina, Andrzej J Bojarski, Emanuele Amata, Katarzyna Kieć-Kononowicz
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H 3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties. ACS chemical neuroscience 13 (1) (2021)
Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Markus Falkenstein, Mariam Dubiel, Annika Frank, David Reiner, Holger Stark, Bassem Sadek
The Multi-Targeting Ligand ST-2223 with Histamine H3 Receptor and Dopamine D2/D3 Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and Brain Oxidative Stress in Mice. International journal of molecular sciences 22 (4) (2021)
Pedro Brandão, Óscar López, Luisa Leitzbach, Holger Stark, José G Fernández-Bolaños, Anthony J Burke, Marta Piñeiro
Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors. ACS medicinal chemistry letters 12 (11) (2021)
Bisera Stepanovska Tanturovska, Aleksandra Zivkovic, Faik Imeri, Thomas Homann, Burkhard Kleuser, Holger Stark, Andrea Huwiler
ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules (Basel, Switzerland) 26 (17) (2021)
Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L Jayaraj, David Reiner, Shreesh K Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice. International journal of molecular sciences 21 (11) (2020)
Nermin Eissa, Petrilla Jayaprakash, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism. Biomolecules 10 (9) (2020)
Holger Stark
The chemical probe - scopes, limitations and challenges. Expert opinion on drug discovery 15 (12) (2020)
Bisera Stepanovska, Aleksandra Zivkovic, Gaby Enzmann, Silvia Tietz, Thomas Homann, Burkhard Kleuser, Britta Engelhardt, Holger Stark, Andrea Huwiler
Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis. International journal of molecular sciences 21 (18) (2020)
Jens Hagenow, Stefanie Hagenow, Kathrin Grau, Mohammad Khanfar, Lena Hefke, Ewgenij Proschak, Holger Stark
Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs. Drug design, development and therapy 14 (2020)
Nakisa Ghamari, Siavoush Dastmalchi, Omid Zarei, José-Antonio Arias-Montaño, David Reiner, Fulya Ustun Alkan, Holger Stark, Maryam Hamzeh-Mivehroud
In silico and in vitro studies of two non-imidazole multiple targeting agents at histamine H3 receptors and cholinesterase enzymes. Chemical biology & drug design 95 (2) (2019)
Abdelhakim Salem, Rabeia Almahmoudi, Jaana Hagström, Holger Stark, Dan Nordström, Tuula Anneli Salo, Kari K Eklund
Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus. International journal of molecular sciences 20 (7) (2019)
Cecilia Lanzi, Laura Lucarini, Mariaconcetta Durante, Silvia Sgambellone, Alessandro Pini, Stefano Catarinicchia, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Holger Stark, Emanuela Masini
Role of Histamine H₃ Receptor Antagonists on Intraocular Pressure Reduction in Rabbit Models of Transient Ocular Hypertension and Glaucoma. International journal of molecular sciences 20 (4) (2019)
Nakisa Ghamari, Omid Zarei, David Reiner, Siavoush Dastmalchi, Holger Stark, Maryam Hamzeh-Mivehroud
Histamine H3 receptor ligands by hybrid virtual screening, docking, molecular dynamics simulations, and investigation of their biological effects. Chemical biology & drug design 93 (5) (2019)
Katarzyna Popiolek-Barczyk, Dorota Łażewska, Gniewomir Latacz, Agnieszka Olejarz, Wioletta Makuch, Holger Stark, Katarzyna Kieć-Kononowicz, Joanna Mika
Antinociceptive effects of novel histamine H3 and H4 receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse. British journal of pharmacology 175 (14) (2018)
Annika Frank, Dóra J Kiss, György M Keserű, Holger Stark
Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor. Scientific reports 8 (1) (2018)
Alaa Alachkar, Dorota Łażewska, Gniewomir Latacz, Annika Frank, Agata Siwek, Annamaria Lubelska, Ewelina Honkisz-Orzechowska, Jadwiga Handzlik, Holger Stark, Katarzyna Kieć-Kononowicz, Bassem Sadek
Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats. International journal of molecular sciences 19 (11) (2018)
Óscar M Bautista-Aguilera, Stefanie Hagenow, Alejandra Palomino-Antolin, Víctor Farré-Alins, Lhassane Ismaili, Pierre-Louis Joffrin, M Luisa Jimeno, Ondrej Soukup, Jana Janočková, Lena Kalinowsky, Ewgenij Proschak, Isabel Iriepa, Ignacio Moraleda, Johannes S Schwed, Alejandro Romero Martínez, Francisco López-Muñoz, Mourad Chioua, Javier Egea, Rona R Ramsay, José Marco-Contelles, Holger Stark
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases. Angewandte Chemie (International ed. in English) 56 (41) (2017)
Annika Frank, Saleh Abu-Lafi, Azmi Adawi, Johannes S Schwed, Holger Stark, Anwar Rayan
From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 66 (10) (2017)