Reply to Letter to the Editor regarding "Oncological outcomes of squamous cell carcinoma of the cervical esophagus treated with definitive (chemo-)radiotherapy: a systematic review and meta-analysis".
Armando De VirgilioAndrea CostantinoBianca Maria FestaGiuseppe MercanteDavide FranceschiniCiro FranzeseMarta ScorsettiAndrea MarrariRaffaele CavinaSalvatore MaranoCarlo CastoroGiuseppe SprianoPublished in: Journal of cancer research and clinical oncology (2022)
In a previous study, we performed a meta-analysis of the oncological outcomes of patients suffering from cervical esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Further analysis was performed, and a random effect modeling showed a pooled local-regional failure rate of 41.4% (95% CI 32.2-50.8), and a pooled distant failure rate of 21.6% (95% CI 17.0-26.5). The included studies used a median radiotherapy (RT) dose of 61.2 Gy (95% CI 60.0-62.0, range 56.0-66.0), but we measured a non-significant impact of the RT dose on the pooled overall survival (OS), suggesting that an increased RT dose might not be related to an improved OS (p = 0.23). Further research should be conducted to define predictors and prognostic categories that may select the best treatment option for each patient.
Keyphrases
- locally advanced
- rectal cancer
- squamous cell carcinoma
- newly diagnosed
- radiation therapy
- end stage renal disease
- early stage
- chronic kidney disease
- radical prostatectomy
- prognostic factors
- prostate cancer
- lymph node
- case report
- combination therapy
- phase iii
- photodynamic therapy
- randomized controlled trial
- peritoneal dialysis
- patient reported outcomes
- clinical trial
- type diabetes
- study protocol
- lymph node metastasis
- metabolic syndrome
- cancer therapy
- weight loss
- data analysis