Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men.

Jason Garcia Kirsten D Krieger Candice Loitz Lillian M Perez Zachary A Richards Yves Helou Steven Kregel Sasha Celada Clementina A Mesaros Maarten C Bosland Peter H Gann Thomas E Willnow Donald J Vander Griend Rick A Kittles Gail S Prins Trevor M Penning Larisa Nonn

Published in: Cancer research communications (2023)

These findings link vitamin D deficiency and the megalin protein to increased levels of prostate androgens, which may underpin the disparity in lethal prostate cancer in African America men.

Keyphrases

prostate cancer
african american
radical prostatectomy
benign prostatic hyperplasia
middle aged
small molecule
binding protein
amino acid