TNF is a homoeostatic regulator of distinct epigenetically primed human osteoclast precursors.
Cecilia AnsaloneJohn ColeSabarinadh ChilakaFlavia SunziniShatakshi SoodJamie RobertsonStefan SiebertIain B McInnesCarl S GoodyearPublished in: Annals of the rheumatic diseases (2021)
These findings fundamentally re-define the relationship between RANK-L and TNF. Moreover, they have identified a novel pool of human circulating non-MO OC precursors that unlike MOs are epigenetically preconditioned to ignore TNF-mediated signalling. In RA, this epigenetic preconditioning occurs in the MO compartment providing a pathological consequence of failure of this pathway.
Keyphrases
- rheumatoid arthritis
- endothelial cells
- induced pluripotent stem cells
- pluripotent stem cells
- gene expression
- long noncoding rna
- transcription factor
- quantum dots
- disease activity
- ankylosing spondylitis
- gold nanoparticles
- systemic sclerosis
- cerebral ischemia
- highly efficient
- interstitial lung disease
- reduced graphene oxide