Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C-C Motif Chemokine Ligand 2-Mediated Angiocrine Signaling.
Jinhang GaoBo WeiMengfei LiuPetra HirsovaTejasav S SehrawatSheng CaoXiao HuFei XueUsman YaqoobNingling KangHuarui CuiWilliam C K PomerantzEnis KostallariVijay H ShahPublished in: Hepatology (Baltimore, Md.) (2021)
In summary, endothelial p300 interaction with NFκB and BRD4 increases CCL2 expression, leading to macrophage accumulation, portal hypertension, and liver fibrosis. Inhibition of p300 and its binding partners might serve as therapy in the treatment of liver diseases.