Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: A proof of concept study.

C Anton FriesShari D LawsonLin C WangKai V SlaughterPraveen K VemulaAshish DhayaniNitin JoshiJeffrey M KarpRory F RickardVijay S GorantlaMichael R Davis

Published in: PloS one (2019)

Graft-implanted TAC-loaded hydrogel delays the onset of Grade IV AR of mismatched porcine forelimb VCA grafts, resulting in long term graft survival and demonstrates dose-dependent tolerability.

Keyphrases

drug delivery
cancer therapy
wound healing
hyaluronic acid
open label
tissue engineering
clinical trial
randomized controlled trial
free survival