A new lead to NLRP3 inhibition.

Published in: The Journal of experimental medicine (2017)

The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).

Keyphrases

small molecule
endothelial cells
protein protein
nlrp inflammasome
induced pluripotent stem cells
pluripotent stem cells
angiotensin converting enzyme
high throughput