Effect of Inflammatory Signaling on Human Articular Chondrocyte Hypertrophy: Potential Involvement of Tissue Repair Macrophages.
Mauricio N Ferrao BlancoYvonne M Bastiaansen-JenniskensMark G ChambersAndrew A PitsillidesRoberto NarcisiGerjo J V M van OschPublished in: Cartilage (2021)
Intrinsic inflammatory signaling activation is not involved in the hypertrophic shift observed in human articular chondrocytes cultured in vitro. However, tissue repair macrophages may contribute to the onset of this detrimental phenotype in human osteoarthritic cartilage, given the effect observed in our experimental models.