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Elimination of GGTA1, CMAH, β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions.

Jing XuJilong RenKai XuMinghui FangMeina KaFei XuXin WangJing WangZhiqiang HanGuihai FengYing ZhangTang HaiWei LiZheng Hu
Published in: Animal models and experimental medicine (2024)
4KO piglets have lower immunogenicity, are safe in genomic level, and are easier to breed than the model with both MHC I and II deletion.
Keyphrases
  • endothelial cells
  • induced pluripotent stem cells
  • genome wide
  • pluripotent stem cells
  • bioinformatics analysis
  • transcription factor