Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction.
Qiuyu SunBerna GüvenCory S WaggAmanda Almeida de OliveiraHeidi SilverLiyan ZhangBrandon ChenKaleigh WeiEzra B KetemaQutuba G KarwiKaya L PersadJennie VuFaqi WangJason R B DyckGavin Y OuditGary D LopaschukPublished in: Cardiovascular research (2024)
In HFpEF, fatty acid oxidation dominates as the major source of cardiac ATP production at the expense of insulin-stimulated glucose oxidation.