Amantadine prevented hypersensitivity and decreased oxidative stress by NMDA receptor antagonism after spinal cord injury in rats.
Alfonso Mata-BermudezCamilo RíosMasha BureloCuauhtémoc Pérez-GonzálezBetzabé Anahí García-MartínezGustavo Jardon-GuadarramaFrancisco Calderón-EstrellaNorman Manning-BalpuestaAraceli Díaz-RuizPublished in: European journal of pain (London, England) (2021)
This study suggests that acute treatment with amantadine decreases hypersensitivity threshold and frequency of hypersensitivity response in a dose-dependent manner, in rats with SCI, by decreasing oxidative stress. Since amantadine is an easily accessible drug and has fewer adverse effects than current treatments for hypersensitivity threshold and frequency of hypersensitivity response, amantadine could represent a safe and effective therapy for the treatment of neuropathic pain. However, further research is required to provide evidence of the effectiveness and feasibility.
Keyphrases
- drug induced
- neuropathic pain
- spinal cord
- oxidative stress
- spinal cord injury
- dna damage
- randomized controlled trial
- emergency department
- liver failure
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- signaling pathway
- respiratory failure
- combination therapy
- intensive care unit
- adverse drug
- hepatitis b virus
- heat shock
- heat shock protein