Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer.

Ann HannaMellissa J NixonM Valeria EstradaVioleta SanchezQuanhu ShengSusan R OpalenikAbigail L TorenJoshua BauerPhillip OwensFrank M MasonRebecca S CookMelinda E SandersCarlos L ArteagaJustin M Balko

Published in: Breast cancer research : BCR (2022)

This study identifies a novel mechanism for breast tumorigenesis implicating Dusp4 loss and p53 mutations in cellular acquisition of Dbf4 upregulation as a driver of cellular replication and cell cycle checkpoint escape.

Keyphrases

cell cycle
cell proliferation
genome wide
poor prognosis
signaling pathway
nucleic acid
oxidative stress
heat stress