Antiretroviral Therapy Intensification for Neurocognitive Impairment in HIV.
Scott L LetendreHuichao ChenAshley McKhannJhoanna RoaAlyssa VecchioEric S DaarBaiba BerzinsPeter W HuntChristina M MarraThomas B CampbellRobert W CoombsQing MaShobha SwaminathanBernard J C MacatangayGene D MorseThomas MillerDavid RusinAlexander L GreningerBelinda HaBeverly Alston-SmithKevin RobertsonRobert PaulSerena Spudichnull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
This is the largest, randomized, placebo-controlled trial of ART intensification for NCI in PWH. The findings do not support empiric ART intensification as a treatment for NCI in PWH on suppressive ART. They also do not support that DTG adversely affects cognition, mood, or weight.
Keyphrases
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- hiv positive
- hiv infected patients
- hiv aids
- double blind
- bipolar disorder
- placebo controlled
- open label
- body mass index
- mild cognitive impairment
- clinical trial
- white matter
- weight loss
- phase iii
- phase ii
- study protocol
- weight gain
- body weight
- randomized controlled trial
- depressive symptoms