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Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord.

Bing WangLi-Na WangBin WuRan GuoLi ZhangJiang-Tao ZhangZhi-Hong WangFeng WuYu FengHong LiuXiao-Hong JinXiu-Hua MiaoTong Liu
Published in: Anesthesiology (2023)
Astrocyte ER stress sensors PERK and IRE1 facilitated morphine tolerance and hyperalgesia through upregulation of LCN2 and NLRP3 in the spinal cord.
Keyphrases
  • nlrp inflammasome
  • spinal cord
  • endoplasmic reticulum stress
  • neuropathic pain
  • poor prognosis
  • spinal cord injury
  • cell proliferation
  • signaling pathway
  • endoplasmic reticulum
  • low cost
  • long non coding rna