Evaluation of the effect of mitoquinone on functional parameters, DNA structure, and genes expression related to the apoptotic and antioxidants of human sperm after freezing-thawing.

Tohid Moradi Gardeshi Erfan Shahandeh Nafiseh Tavakolpoor Saleh Somayeh Karami Zahra Mirzaei Azandaryani Fahimeh Mazaheri Hiwa Mohammadi

Published in: Molecular biology reports (2024)

Adding the optimal concentration of MitoQ (2 nM) to the sperm freezing medium not only improves sperm functional parameters and reduces DNA damages, but also stimulates the expression of antioxidant genes, leading to even greater benefits for sperm cryopreservation.

Keyphrases

poor prognosis
circulating tumor
endothelial cells
genome wide
cell free
single molecule
cell death
anti inflammatory
oxidative stress
binding protein
photodynamic therapy
long non coding rna
gene expression
nucleic acid
genome wide analysis
drug induced