Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia.

Shiying HaoJin YouLin ChenHui ZhaoYujuan HuangLe ZhengLu TianIvana MaricXin LiuTian LiYlayaly K BiancoVirginia D WinnNima AghaeepourBrice GaudilliereMartin S AngstXin ZhouYu-Ming LiLihong MoRonald J WongGary M ShawDavid K StevensonHarvey J CohenDoff B McelhinneyKarl G SylvesterXuefeng Bruce Ling

Published in: PloS one (2020)

Serum placenta-related protein profiles are temporally regulated throughout normal pregnancies and significantly disrupted in women who develop PE. LEP changes earlier than the well-established biomarkers (sFlt-1 and PlGF). There may be evidence of a causative action of HO-1 deficiency in LEP upregulation in a PE-like murine model.

Keyphrases

pregnancy outcomes
preterm birth
pregnant women
gestational age
preterm infants
polycystic ovary syndrome
poor prognosis
transcription factor
signaling pathway
resting state
pi k akt
adipose tissue
functional connectivity
replacement therapy
cervical cancer screening
breast cancer risk