Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation.
Florian EmmerichStefan ZschiedrichChristine Reichenbach-BraunCaner SüsalSusana MinguetMarie-Christin PaulyMaximilian SeidlPublished in: Molecules (Basel, Switzerland) (2021)
Acute and chronic transplant rejections due to alloreactivity are essential contributors to graft loss. However, the strength of alloreactivity is biased by non-immunological factors such as ischemia reperfusion injury (IRI). Accordingly, protection from IRI could be favorable in terms of limiting graft rejection. Caveolin-1 (Cav-1) is part of the cell membrane and an important regulator of intracellular signaling. Cav-1 has been demonstrated to limit IRI and to promote the survival of a variety of cell types including renal cells under stress conditions. Accordingly, Cav-1 could also play a role in limiting anti-graft immune responses. Here, we evaluated a possible association between pre-transplant serum concentrations of Cav-1 and the occurrence of rejection during follow-up in a pilot study. Therefore, Cav-1-serum concentrations were analyzed in 91 patients at the time of kidney transplantation and compared to the incidence of acute and chronic rejection. Higher Cav-1 levels were associated with lower occurrence of acute cellular tubulointerstitial rejection episodes.
Keyphrases
- kidney transplantation
- liver failure
- respiratory failure
- drug induced
- immune response
- aortic dissection
- ischemia reperfusion injury
- risk assessment
- oxidative stress
- stem cells
- hepatitis b virus
- risk factors
- cell proliferation
- transcription factor
- cell death
- bone marrow
- cell cycle arrest
- heat stress
- pi k akt
- diabetic nephropathy
- endoplasmic reticulum stress