Apigenin Reverses Interleukin-1β-Induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes.
Meshail OklaJamal Omran Al MadaniSoonkyu ChungMusaad AlfayezPublished in: Molecular nutrition & food research (2019)
Apg plays a protective role against inflammation-induced suppression of adipocyte browning by dampening inflammation and activating the COX2/PGE2 axis for uncoupling protein 1 induction via EP4 activation. These data unravel the novel therapeutic values of Apg for treating obesity via adipocyte browning stimulation.
Keyphrases
- insulin resistance
- high fat diet induced
- adipose tissue
- signaling pathway
- oxidative stress
- high glucose
- diabetic rats
- endothelial cells
- fatty acid
- metabolic syndrome
- type diabetes
- weight loss
- drug induced
- skeletal muscle
- induced apoptosis
- machine learning
- artificial intelligence
- deep learning
- protein protein
- endoplasmic reticulum stress