The effect of CYP2D6 and CYP2C9 gene polymorphisms on the efficacy and safety of the combination of tramadol and ketorolac used for postoperative pain management in patients after video laparoscopic cholecystectomy.
Andranik Alexandrovich MuradianDmitry Alekseevich SychevDmitry Alekseevich BlagovestnovZhannet Alimovna SozaevaKristina Anatolyevna AkmalovaMichael Sergeevich ZastrozhinLeyla Nabievna KerimovaVadim Teymurazovich KoroshviliIrina Alexandrovna EpifanovaPublished in: Drug metabolism and personalized therapy (2021)
CYP2D6 and CYP2C9 can predict analgesic effectiveness of tramadol and ketorolac. CYP2C9 can predict the risk of gastrointestinal bleeding, including those hidden to ketorolac.