The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells.
Tatsuya IharaTakahiko MitsuiYuki NakamuraMie KandaSachiko TsuchiyaSatoru KiraHiroshi NakagomiNorifumi SawadaYuri HirayamaKeisuke ShibataEiji ShigetomiYoichi ShinozakiMitsuharu YoshiyamaAtsuhito NakaoMasayuki TakedaSchuichi KoizumiPublished in: Neurourology and urodynamics (2017)
We demonstrated that the time-dependent gene expressions, including clock genes, mechano-sensors, and ARMM, were reproducible in UCs. These findings demonstrated that UCs have the potential to progress research into the circadian functions of the lower urinary tract regulated by clock genes.
Keyphrases
- urinary tract
- genome wide
- genome wide identification
- poor prognosis
- bioinformatics analysis
- induced apoptosis
- dna methylation
- transcription factor
- binding protein
- copy number
- spinal cord injury
- long non coding rna
- high grade
- neuropathic pain
- oxidative stress
- cell death
- climate change
- cell proliferation
- signaling pathway