Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.
Anna J JasinskaIvette ZelayaSusan K ServiceChristine B PetersonRita M CantorOi-Wa ChoiJoseph DeYoungEleazar EskinLynn A FairbanksScott FearsAllison E FurtererYu S HuangVasily RamenskyChristopher A SchmittHannes SvardalMatthew J JorgensenJay R KaplanDiego VillarBronwen L AkenPaul FlicekRishi NagEmily S WongJohn BlangeroThomas D DyerMarina BogomolovYoav BenjaminiGeorge M WeinstockKen DewarChiara SabattiRichard K WilsonJ David JentschWesley WarrenGiovanni CoppolaRoger P WoodsNelson A FreimerPublished in: Nature genetics (2017)
By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
Keyphrases
- genome wide
- dna methylation
- gene expression
- poor prognosis
- copy number
- endothelial cells
- binding protein
- high resolution
- machine learning
- transcription factor
- cerebral ischemia
- induced pluripotent stem cells
- electronic health record
- big data
- genome wide association study
- single cell
- functional connectivity
- mass spectrometry