Potential type 2 diabetes mellitus drug HMPA promotes short-chain fatty acid production by improving carbon catabolite repression effect of gut microbiota.

Huijuan LiuYuan QinKun LiMeng LiJiahuan YangHonglian TaoYuanhao TangLan YangShuang ChenYanrong LiuCheng YangWenqing GaoTao Sun

Published in: British journal of pharmacology (2021)

HMPA plays a hypoglycaemic role through the gut microbiota. HMPA improves the carbon catabolite repression effect of gut microbiota and increases SCFAs production by targeting GlnR. GlnR may be a target for gut microbiota regulation.

Keyphrases

fatty acid
type diabetes
emergency department
risk assessment
glycemic control
insulin resistance