Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

Iris J Broce Celeste M KarchNatalie WenChun C FanYunpeng Wang Chin Hong Tan Naomi KouriOwen A RossGünter U HöglingerUlrich MullerJohn Hardynull nullParastoo MomeniChristopher P HessWilliam P DillonZachary A Miller Luke W BonhamGil D RabinoviciHoward J RosenGerard D SchellenbergAndre FrankeTom H KarlsenJan Herman VeldinkRaffaele FerrariJennifer S YokoyamaBruce L MillerOle A AndreassenAnders M Dale Rahul S Desikan Leo P Sugrue

Published in: PLoS medicine (2018)

We show immune-mediated genetic enrichment specifically in FTD, particularly within the HLA region. Our genetic results suggest that for a subset of patients, immune dysfunction may contribute to FTD risk. These findings have potential implications for clinical trials targeting immune dysfunction in patients with FTD.

Keyphrases

clinical trial
genome wide
end stage renal disease
genome wide association
copy number
oxidative stress
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
risk assessment
dna methylation
human health
patient reported outcomes
climate change