Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy.

Seo Rin KimAmrutesh S PuranikKai JiangXiaojun ChenXiang-Yang ZhuIan TaylorAlireza Khodadadi-JamayranAmir LermanLaTonya J HicksonBennett G ChildsStephen C TextorTamara TchkoniaTimothy B NiewoldJames L KirklandLilach Orly Lerman

Published in: Journal of the American Society of Nephrology : JASN (2021)

Maladaptive tubular cell senescence, involving upregulated p16 (Cdkn2a), p19 (Cdkn2d), and p21 (Cdkn1a) expression, is associated with renal dysfunction and injury in chronic ischemia. These findings support development of senolytic strategies to delay chronic ischemic renal injury.

Keyphrases

dna damage
oxidative stress
endothelial cells
poor prognosis
multiple sclerosis
single cell
ischemia reperfusion injury
cell therapy
stress induced
binding protein
drug induced
long non coding rna
bone marrow