Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16INK4a and frailty.
Andrew B SmithermanWilliam A WoodNatalia MitinVanessa L Ayer MillerAllison M DealIan J DavisJulie BlattStuart H GoldHyman B MussPublished in: Cancer (2020)
Chemotherapy is associated with increased cellular senescence and molecular age in pediatric and young adult cancer survivors. Frail survivors, compared with robust survivors, exhibit higher levels of p16INK4a , suggesting that cellular senescence may be associated with early aging in survivors.