The in vitro Mycobacterium bovis BCG Moreau infection of human monocytes that induces Caspase-1 expression, release and dependent cell death is mostly reliant upon cell integrity.
Paulo Renato Zuquim AntasCarlos G G PonteMatheus R AlmeidaLawrence H P AlbuquerquePeriela S Sousa-VasconcelosThaíze PedroNatália L S GomesOtacílio C MoreiraFernanda C SilvaLuíz R R Castello-BrancoRosa T PinhoPublished in: Journal of inflammation (London, England) (2019)
Our data directly corroborate other findings showing that BCG Moreau led to an increased secretion of IL-1β but not IL-18, two Caspase-1-activated cytokines, and are also in support of the model that the BCG Moreau infection of human mononuclear cells may induce a cell-death pattern involving Caspase-1 activation.