Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation.
Monica Sofia Ventura FerreiraMia Dahl SørensenStefan PuschDagmar BeierAnne-Sophie BouillonBjarne Winther KristensenTim Henrik BrümmendorfChristoph Patrick P BeierFabian BeierPublished in: Journal of neuro-oncology (2020)
ALT is the major telomere maintenance mechanism in IDHR132H mutated astrocytomas, while TERT promoter mutations were associated with IDHwildtype glioma. IDH1R132H downregulates ATRX expression in vitro resulting in ALT, which may contribute to the strong association of IDH1R132H mutations, ATRX loss, and ALT.