Reproducible disease phenotyping at scale: Example of coronary artery disease in UK Biobank.
Riyaz S PatelSpiros DenaxasLaurence J HoweRosalind M EggoAnoop D ShahNaomi E AllenJohn DaneshAroon HingoraniCathie SudlowHarry HemingwayPublished in: PloS one (2022)
An algorithmic, EHR-based approach distinguished six phenotypes of CAD with distinct survival and PRS associations, supporting adoption of open approaches to help standardize CAD phenotyping and its wider potential value for reproducible research in other conditions.
Keyphrases
- coronary artery disease
- high throughput
- electronic health record
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- minimally invasive
- cross sectional
- aortic stenosis
- human health
- single cell
- risk assessment
- acute coronary syndrome
- climate change
- atrial fibrillation
- left ventricular