A novel biomarker of fibrofatty replacement in dystrophinopathies identified by integrating transcriptome, magnetic resonance imaging, and pathology data.

Zhihao XieChang LiuChengyue SunYanyu LuShiyi WuYilin LiuQi WangYalan WanYikang WangMeng YuLingchao MengJianwen DengWei ZhangZhaoxia WangChunxia YangYun YuanZhiying Xie

Published in: Journal of cachexia, sarcopenia and muscle (2023)

We identify CDKN2A expression as a novel biomarker of fibrofatty replacement, which might be a new target for antifibrotic therapy in dystrophinopathies.

Keyphrases

magnetic resonance imaging
poor prognosis
gene expression
computed tomography
electronic health record
rna seq
single cell
big data
contrast enhanced
stem cells
long non coding rna
machine learning
mesenchymal stem cells
magnetic resonance
cell therapy
deep learning
diffusion weighted imaging