EZH2-regulated PARP 1 Expression is a Likely Mechanism for the Chemoresistance of Gliomas to Temozolomide.

Qiang LiangBing WangChenran ZhangChaoli SongJunyu WangWei SunLei JiangJing Lin

Published in: Current cancer drug targets (2023)

EZH2 PARP 1 signaling axis is possibly responsible for the chemoresistance of gliomas to TMZ. Simultaneously inhibiting these two genes may improve the outcome of TMZ chemotherapy.

Keyphrases

high grade
dna damage
dna repair
poor prognosis
long non coding rna
long noncoding rna
signaling pathway
transcription factor
genome wide
cancer stem cells
newly diagnosed
binding protein
genome wide identification
bioinformatics analysis