The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Vijayalakshmi KariSanjay Kumar RaulJana Maria HenckJulia KitzFrank KramerRobyn Laura KosinskyNadine ÜbelmesserWael Yassin MansourJessica EggertMelanie SpitznerZeynab NajafovaHolger BastiansMarian GradeJochen GaedckeFlorian WegwitzSteven A JohnsenPublished in: Clinical epigenetics (2019)
In this study, we conclude that DOT1L plays an important role in an early DNA damage response and repair of DNA double-strand breaks via the HR pathway. Moreover, DOT1L inhibition leads to increased sensitivity to chemotherapeutic agents and PARP inhibition, which further highlights its potential clinical utility. Our results further suggest that H3K79me3 can be useful as a predictive and or prognostic marker for rectal cancer patients.