Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes.
Marialbert Acosta-HerreraMartin KerickElena Lopéz-IsacShervin AssassiLorenzo BerettaCarmen Pilar Simeón-AznarNorberto Ortego-Centenonull nullSusanna M Proudmannull nullNicolas HunzelmannGianluca MoronciniJeska K de Vries-BouwstraGisela OrozcoRichard B WarrenAriane L HerrickChikashi TeraoYannick AllanoreMatthew A BrownTimothy Rdj RadstakeCarmen FonsecaChristopher P DentonMaureen D MayesJavier MartínPublished in: Annals of the rheumatic diseases (2021)
This study confirms the contribution of HLA class II and reveals a novel association of HLA class I with SSc, suggesting novel pathways of disease pathogenesis. Furthermore, we describe specific HLA associations with SSc clinical and serological subtypes that could serve as biomarkers of disease severity and progression.