Acute administration of ibuprofen increases serum concentration of the neuroprotective kynurenine pathway metabolite, kynurenic acid: a pilot randomized, placebo-controlled, crossover study.
Jonathan B SavitzBart N FordRayus KuplickiSahib KhalsaT Kent TeagueMartin P PaulusPublished in: Psychopharmacology (2022)
Given its KynA-elevating effects, ibuprofen could have neuroprotective effects in the context of depression as well as other neuroinflammatory disorders that are characterized by a reduction in KynA.
Keyphrases
- placebo controlled
- liver failure
- double blind
- depressive symptoms
- respiratory failure
- postoperative pain
- sleep quality
- aortic dissection
- study protocol
- cerebral ischemia
- randomized controlled trial
- clinical trial
- phase ii
- hepatitis b virus
- phase ii study
- physical activity
- blood brain barrier
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- locally advanced