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Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS-like tyrosine kinase 3-internal tandem duplication with central nervous system involvement.

Makiko SugaKentaro FukushimaTomoaki UedaYasuyuki AraiShunsaku NakagawaYosuke MinamiJun TodaAkihisa HinoJiro FujitaTakafumi YokotaNaoki Hosen
Published in: Clinical case reports (2022)
FMS-like tyrosine kinase 3-internal tandem duplication ( FLT3 -ITD) mutation-positive acute myeloid leukemia (AML) has a poor prognosis. We report the first case of successful bridge therapy of novel FLT3 inhibitor, quizartinib, to umbilical cord blood stem cell transplantation for FLT3 -ITD-positive AML-primary induction failure patients with central nervous system involvement.
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