Fixed airflow obstruction relates to eosinophil activation in asthmatics.

Ida MogensenKjell AlvingSven-Erik DahlenAnna JamesBertil ForsbergJunya OnoShoichiro OhtaPer VengeMagnus P BorresKenji IzuharaChrister JanssonAndrei Malinovschi

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)

These findings support that type 2 inflammation, and in particular eosinophil inflammation, is found in asthma with fixed-AO. This could indicate a benefit from eosinophil-directed therapies. Further longitudinal studies are warranted to investigate causality and relation to lung function decline.

Keyphrases

lung function
chronic obstructive pulmonary disease
cystic fibrosis
oxidative stress
air pollution
emergency department
cross sectional
case control
adverse drug