Mimicking Clinical Trials Using Real-World Data: A Novel Method and Applications.

Wei-Jhih Wang Aasthaa BansalCaroline Savage BennetteAnirban Basu

Published in: Medical decision making : an international journal of the Society for Medical Decision Making (2022)

The correlation structure is crucial to building the joint distribution of patient characteristics, and a misspecified correlation structure could potentially influence predicted outcomes.An iterative algorithm was developed to approximate a trial's correlation structure using published summary trial data and real-world data.The algorithm could be a feasible way to simulate individual-level trial data when only trial summary data are available.

Keyphrases

clinical trial
electronic health record
phase iii
study protocol
phase ii
big data
machine learning
randomized controlled trial
deep learning
magnetic resonance imaging
metabolic syndrome
computed tomography
skeletal muscle
type diabetes
weight loss
insulin resistance