Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute-on-Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid-Dependent Monocyte Activation.
Francesca M TrovatoRabiya ZiaSalvatore NapoliKate WolferXiaohong HuangPhillip E MorganHannah HusbynMarwa ElgosbiManuele LucangeliRosa MiquelIan WilsonNigel David HeatonMichael A HeneghanGeorg AuzingerCharalambos G AntoniadesJulia A WendonVishal C PatelMuireann CoenEvangelos TriantafyllouMark J W McPhailPublished in: Hepatology (Baltimore, Md.) (2021)
ATX up-regulation in ACLF promotes LPA production from LPC. LPA suppresses MerTK/CD163 expression and increases monocyte proinflammatory cytokine production. This metabolic pathway could be investigated to therapeutically reprogram monocytes in ACLF.