Elicitation of prior probability distributions for a proposed Bayesian randomized clinical trial of whole blood for trauma resuscitation.
Jan O JansenHenry E WangJohn B HolcombJohn A HarvinJoshua RichmanElenir AvritscherShannon W StephensVan Thi Thanh TruongMarisa B MarquesStacia M DeSantisJose-Miguel YamalClaudia PedrozaPublished in: Transfusion (2020)
Experts had moderately strong beliefs that whole blood reduces the 24-hour mortality of trauma patients with hemorrhagic shock. These data will assist with the design and planning of a Bayesian trial of whole blood resuscitation, which will help to answer a key question in contemporary transfusion practice.
Keyphrases
- cardiac arrest
- cardiopulmonary resuscitation
- trauma patients
- septic shock
- primary care
- healthcare
- blood pressure
- clinical trial
- study protocol
- electronic health record
- cardiac surgery
- cardiovascular events
- phase iii
- phase ii
- big data
- risk factors
- type diabetes
- sickle cell disease
- double blind
- cardiovascular disease
- randomized controlled trial
- machine learning
- acute kidney injury
- open label
- monte carlo