Lower versus higher blood pressure targets in comatose patients resuscitated from out-of-hospital cardiac arrest-Protocol for a secondary Bayesian analysis of the box trial.
Johannes GrandSebastian WibergJesper KjaergaardChristian HassagerHenrik SchmidtJacob E MøllerSimon MølstrømAnders GranholmPublished in: Acta anaesthesiologica Scandinavica (2024)
This secondary analysis of the BOX trial aim to complement the primary frequentist analysis by quantifying the probabilities of beneficial or harmful effects of different blood pressure targets. This approach seeks to provide clearer insights for researchers and clinicians into the effectiveness of these blood pressure management strategies in acute medical conditions, particularly focusing on mortality, neurological outcomes, and neuron-specific enolase.
Keyphrases
- blood pressure
- hypertensive patients
- cardiac arrest
- randomized controlled trial
- end stage renal disease
- heart rate
- study protocol
- clinical trial
- phase iii
- transcription factor
- ejection fraction
- phase ii
- chronic kidney disease
- newly diagnosed
- healthcare
- systematic review
- binding protein
- liver failure
- prognostic factors
- cardiovascular events
- type diabetes
- palliative care
- coronary artery disease
- cardiovascular disease
- adipose tissue
- metabolic syndrome
- skeletal muscle
- brain injury
- acute respiratory distress syndrome
- data analysis
- insulin resistance
- double blind