Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts.
Kyung-Il KimChang-Il KwonJeung-Hoon LeeChang-Deok KimTae-Jin YoonPublished in: Annals of dermatology (2022)
These results suggest that mitoxantrone reduces collagen synthesis by inhibiting TGF-β/SMAD signaling and LARP6 expression in fibroblasts, which can be developed as a therapeutic agent for diseases caused by collagen hypersynthesis.